Bioactive Small Molecules
A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.
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841
Tocris Bioscience™ Pomalidomide 4'-alkylC8-amine
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Cereblon ligand with alkyl linker and terminal amine for onward chemistry
842
Tocris Bioscience™ Janelia Fluor™ 646b, NHS ester
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Blinking fluorescent dye (Reactive group: NHS ester). Application: super resolution microscopy (SRM) including SMLM
843
Tocris Bioscience™ BAY 593
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Geranylgeranyltransferase-I (GGTase-I) inhibitor
844
Tocris Bioscience™ AZ 12799734
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Potent TGF-βRI inhibitor
| CAS | 1117684-36-2 |
|---|---|
| Purity | 98% |
| Chemical Name or Material | 4-[[4-[(2.6-Dimethyl-3-pyridinyl)oxy]-2-pyridinyl]amino]benzenesulfonamide |
| Molecular Formula | C18H18N4O3S |
845
Novus Biologicals™ Imidazoquinoline Resiquimod (R-848), TLR7 and TLR8 ligand
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846
Tocris Bioscience™ ML 252
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Potent and selective KV7.2 inhibitor; brain penetrant
| Target | Voltage-gated Potassium Channel Blockers |
|---|---|
| CAS | 1392494-64-2 |
| Purity | 0.98 |
| Chemical Name or Material | (S)-2-Phenyl-N-(2-(pyrrolidin-1-yl)phenyl)butanamide |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C20H24N2O |
847
Thermo Scientific™ Fosinopril (sodium), 98%
CAS: 88889-14-9 Molecular Formula: C30H45NNaO7P Molecular Weight (g/mol): 585.65 MDL Number: MFCD00897699 InChI Key: TVTJZMHAIQQZTL-HREVRLCXSA-M IUPAC Name: sodium (2S,4S)-4-cyclohexyl-1-(2-{[2-methyl-1-(propanoyloxy)propoxy](4-phenylbutyl)phosphoryl}acetyl)pyrrolidine-2-carboxylate SMILES: [Na+].CCC(=O)OC(OP(=O)(CCCCC1=CC=CC=C1)CC(=O)N1C[C@@H](C[C@H]1C([O-])=O)C1CCCCC1)C(C)C
| CAS | 88889-14-9 |
|---|---|
| Molecular Weight (g/mol) | 585.65 |
| MDL Number | MFCD00897699 |
| SMILES | [Na+].CCC(=O)OC(OP(=O)(CCCCC1=CC=CC=C1)CC(=O)N1C[C@@H](C[C@H]1C([O-])=O)C1CCCCC1)C(C)C |
| IUPAC Name | sodium (2S,4S)-4-cyclohexyl-1-(2-{[2-methyl-1-(propanoyloxy)propoxy](4-phenylbutyl)phosphoryl}acetyl)pyrrolidine-2-carboxylate |
| InChI Key | TVTJZMHAIQQZTL-HREVRLCXSA-M |
| Molecular Formula | C30H45NNaO7P |
848
Tocris Bioscience™ Janelia Fluor™ 635, Tetrazine
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Red dye (Reactive group: tetrazine). Application: confocal microscopy, super resolution microscopy including dSTORM & STED. Suitable for live cell imaging
849
Tocris Bioscience™ TRPC6-PAM-C20
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Selective TRPC6 positive allosteric modulator
| CAS | 667427-75-0 |
|---|---|
| Purity | 98% |
| Chemical Name or Material | 3-(3-,4-Dihydro-6,7-dimethoxy-3,3-dimethyl-1-isoquinolinyl)-2H-1-benzopyran-2-one |
| Molecular Formula | C22H21NO4 |
850
| Shipping Condition | No special requirements |
|---|---|
| CAS | 64461-82-1 |
| Color | White to Yellow to Light-brown |
| Solubility | Soluble aqueous solution |
| Purity | ≥97.5% |
| Physical Form | Powder |
| Health Hazard 1 | Exclamation mark |
| Chemical Name or Material | Tizanidine hydrochloride |
| Recommended Storage | Normal conditions |
| Synonym | 5-Chloro-4-[(4,5-dihydro-1 H-imidazol-2-yl)amino]-2,1,3-benzothiadiazole hydrochloride |
| Molecular Formula | C9 H8 Cl N5 S . H Cl |
| Melting Point | 280°C |
| Product Line | Life science |
852
Tocris Bioscience™ GSK 2256098
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Potent focal adhesion kinase (FAK) inhibitor
| Target | Focal Adhesion Kinase Inhibitors |
|---|---|
| CAS | 1224887-10-8 |
| Purity | 0.98 |
| Chemical Name or Material | 2-[[5-Chloro-2-[[3-methyl-1-(1-methylethyl)-1H-pyrazol-5-yl]amino]-4-pyridinyl]amino]-N-methoxybenzamide |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C20H23ClN6O2 |
854
| Shipping Condition | No special requirements |
|---|---|
| CAS | 58-46-8 |
| Color | White to Light-yellow to Beige |
| Purity | ≥97.5% |
| Physical Form | Crystalline Powder |
| Health Hazard 1 | Exclamation mark |
| Chemical Name or Material | Tetrabenazine |
| Recommended Storage | Refrigerator +4°C |
| Molecular Formula | C19 H27 N O3 |
| EINECS Number | 200-383-6 |
| Melting Point | 124°C to 130°C |
| Product Line | Life science |
855
Tocris Bioscience™ Ortho AP 1867
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Selective binding ligand for FKBP12F36V; precursor for dTAG compounds
| Target | FKBP12 |
|---|---|
| CAS | 2230613-03-1 |
| Purity | 0.98 |
| Chemical Name or Material | 2-(2-((R)-3-(3,4-Dimethoxyphenyl)-1-(((S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carbonyl)oxy)propyl)phenoxy)acetic acid |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C38H47NO11 |